Resveratrol is a compound found in the skin of grapes and acts as a potent antioxidant and proven anti-aging supplement, boosting brain health and promoting protection from damage to the body that can lead to many diseases.
What is Resveratrol?
Resveratrol is a powerful antioxidant that is touted as an anti-aging supplement. It may even help users lose weight as it is thought to mimic certain metabolic functions related to caloric restrictions.
As a Nootropic, is thought to increase brain circulation, improve energy levels, mood, intelligence and memory and may increase lifespan.
It is a natural polyphenolic compound that is found in small amounts in berries, grapes, peanuts and most famously in red wine. Plants naturally produce it to defend themselves against infections, viruses, stress and UV radiation.
Since the early 90’s, the effects and benefits of Resveratrol have been studied due to the discovery that it is an ingredient in red wine. That gave it the potential for beneficial effects on overall health and especially for cardiovascular health.
Current research supports its use as a potent antioxidant and anti-inflammatory, however, although the body absorbs it well, it gets metabolized and eliminated quickly.
It is sold as a nutritional supplement and is also found in grape seed extract, which also gives it an extra plant-based antioxidant. It can be taken on its own or in longevity promoting Nootropic stacks where it is thought to have some profound effects.
How Resveratrol Works for Anti-Aging & Health
Although there are many theories and debates on how Resveratrol works, it’s main effects seem to promote a natural route for anti-aging and may potentially be a protection from serious health issues.
Resveratrol comes from the skin of grapes. It is one of the compounds from the polyphenol group that is thought to act as an antioxidant by eliminating free radicals (oxidative damage to the cell membranes and DNA) which may help to slow down the ageing process and extend the life of cells.
Polyphenols are also thought to play an important role in health maintenance and lowering the risk of diseases that may be due to free radicals including cancer, heart disease and the accumulation of plaque in Alzheimer’s disease.
Resveratrol is also thought to protect brain cells from free radicals that may cause mental deterioration. It acts in promoting neurogenesis, only killing off cells that the brain deems to be unhealthy and are therefore replaced with healthier new cells.
It also seems to have an association with the activity of enzymes called sirtuins, which play a role in the ageing process and longevity.
Sirtuins are found in all living organisms as one of the body’s natural defense mechanism against disease and free radicals but generally remain non-active.
Resveratrol, is thought to activate a gene called SIRT1 which produces a hormone called adiponectin. This may help fight obesity by potentially speeding up the metabolism.
It is also thought to increase insulin sensitivity, which may improve physical endurance and is also the forerunner of Diabetes. More research needs to be done on Resveratrols direct role in the activity of sirtuins.
It also suggested, that this supplement reduces bad cholesterol called LDL and increases good cholesterol (HDL) levels. It may also prevent the blocking of arteries (cardiovascular disease) and promotes regulation of healthy blood pressure, more in lowering it.
Also, Resveratrol may potentially fight against the risk of age related disorders caused by inflammation. Oxidative stress may cause vascular inflammation and age related inflammation can increase the risk of coronary artery disease and strokes. In almost all diseases, inflammation plays a major role.
Finally, it is suggested that there is some promising evidence that Resveratrol may have anti-cancer effects. It appears that it may affect the potential progression of cells that may lead to breast and prostate cancer. That may be why many people take Resveratrol supplements to lower the risk of developing it.
Benefits of Resveratrol For the Brain
Resveratrol is known to encourage the release of Norepinephrine, also called noradrenalin. This is a hormone that functions in both the body and the brain as a messenger from one neuron to the other and in the cells of muscles and glands.
In the brain, it works to promote alertness and heighten our awareness and focused attention. Users may have a better ability to concentrate and have more mental energy.
It is also thought to work on the retrieval and formation of memory. In studies, Resveratrol has shown to greatly increase the functions of the hippocampus area of the brain.
This area is responsible for organizing, storing and forming memory. Research concluded that this may help users “find their words” and enhance memory capabilities. This may also have anti-aging effects on the memory.
It is also thought to increase oxygen to the brain and improve cerebral blood flow in healthy adults. This allows the brain to get more nutrients.
Our brain uses up 20% of our total daily oxygen and when levels drop this may cause a lack of concentration, the ability to think clearly and reduce our alertness. Oxygen can improve brain performance and that may improve intelligence.
Finally, Resveratrol is thought to be an antioxidant which generally reduces stress and inflammation in the brain and may contain a compound that raises serotonin levels. This may help users improve mood and promote relaxation.
Resveratrol effects may be more short lived than other stronger Nootropics used for cognitive benefits. However, combined with Alcar, it is thought to really enhance memory function. Also, it goes well in combination with Pterostilbene which is a similar compound.
Side Effects of Resveratrol
Resveratrol is reported to be well tolerated, non toxic and appears to be a safe supplement.
Users have taken doses up to 5 grams but this is amount is not recommended and mild stomach aches and nausea have been reported at this dosage level.
It is not recommended for people with blood disorders, conditions related to estrogen levels or people with scheduled surgery less than 2 weeks away.
Also, it may interact with medications for/including blood pressure, cancer treatments, painkillers, MAOI antidepressants, liver and anti-fungal. It should not be taken with St. Johns Wort, Ginkgo Biloba or Garlic supplements.
Resveratrol is found in very small amounts in red wine and you would have to drink up to 1000 bottles a day to experience its full benefits.
There is no established dosage found for Resveratrol as there is still a limited amount of human studies on its effects due to most studies being done on test tubes and animals. The studies on humans have been over short periods of time and cannot determine long-term effects or side effects.
However, the daily recommended dosage in our research suggests between 100mg-500mg per day. When starting on any new Nootropic, it is best to take the lowest dose possible and gauge how it affects you before raising it. It is probably best to start at 10mg per day.
Resveratrol has a short half-life of around 2-5 hours.
You are looking for the highest concentration of Japanese Knotweed or pure extract from grapes or red wine when choosing a Resveratrol supplement for the best results.
If you have any questions or concerns, please consult your doctor first before taking it.
Resveratrol is touted to be one of the best anti-aging supplements with unique antioxidant effects. Although more research is needed to know exactly what Resveratrol can do.
This supplement is unique because it is able to reach the brain and act as an antioxidant. This may protect the brain from free radical damage that may cause cognitive decline.
The body does not naturally produce it and it can be found in small amounts in red wine, peanuts, pistachios, grapes, blueberries, cranberries and dark chocolate.
However, the amount of Resveratrol contained in these foods may be insufficient in boosting health. Some research suggests that red wine offers an appropriate source but drinking excessive amounts of alcohol can have harmful effects.
As a Nootropic, it is thought to boost brain power and may help increase cerebral blood flow. This allows the brain to get more oxygen and nutrients which may help to improve overall cognition.
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