Hordenine supplements are most commonly used to enhance athletic performance and promote weight loss, however, they are also becoming well-known as a Nootropic to promote increased energy levels, enhanced mental focus, concentration and to improve mood.
What is Hordenine?
Hordenine (N, N-dimethyltyramine) is a naturally occurring alkaloid found in many plants like bitter orange and barley (Hordeum vulgare) to which it gets its name and is derived from N-methyltyramine.
This compound is similar to the amino compound tyramine in its structure (found in cheese) and plays a role in releasing hormones such as epinephrine, norepinephrine and dopamine. It is also chemically similar to phenylethylamine.
Hordenine is most well known for its energy boosting qualities and acts as a natural MAO-B inhibitor, gaining popularity as a Nootropic that is used to promote focus, concentration and improve mood.
However, it is most widely marketed as a supplement for exercise performance and weight loss since it has been associated with increasing energy through higher metabolism, decreasing appetite and promoting a faster ability to burn fat during and even after workouts.
This supplement is also available in HCL form (Hordenine HCl) or hydrogen chloride (a salt preparation technique). While both forms are considered by users to produce the same effects, synthetic HCL is considered to take effect much faster as well as lose its effect more rapidly than its organic counterpart.
This article will explore the effects and benefits associated with Hordenine, the potential side effects of this supplement and the commonly reported dosages.
Hordenine Effects and How it Works
Even though the exact mechanisms of action of Hordenine are still not fully understood, it is able to cross the blood-brain barrier and appears to function as a natural monoamine oxidase (MAO-B) inhibitor with effects that include balancing hormone levels and improving nerve communication.
MAO’s are types of enzymes (divided into subclasses A and B depending on what they degrade) found in the outer membrane of mitochondria that are involved in utilizing oxygen to destroy monoamines or hormones when they become excessive.
MAOB is involved in breaking down phenylethylamine and dopamine (mood regulators) and other neurotransmitters. In cases where levels of MAO are excessively high, too many may get destroyed and hormones can become imbalanced. This may lead to problems with mood, energy levels and concentration.
Hordenine works to block and inhibit the activity of this enzyme, which may indirectly result in heightening concentrations of these neurotransmitters. In particular, dopamine referred to as one of “the feel-good chemicals”, promotes a sensation of natural energy, pleasure and focus.
In addition, the adrenergic system is thought to be stimulated, increasing cell metabolism and causing nerve cells to release neurotransmitters like epinephrine and norepinephrine, molecules involved in the “fight or flight” response. This effect may lead to boosting blood flow to the muscles, enhancing energy levels and alertness, although more in an indirect way by inhibiting removal.
Finally, together with its energy promoting effects, Hordenine is known to help burn off the surplus of fatty acids by exposing them to oxygen until the body reaches equilibrium conditions. Additionally, the stimulant-like effects of Hordenine also tend to curb the appetite which is why fitness websites promote this supplement.
Benefits of Hordenine
The main benefits associated with Hordenine is to promote higher overall energy levels that can lead to greater mental focus for most people, which is primarily due to its adrenergic properties.
Hordenine has gained much popularity as a Nootropic supplement used to generate a sense of increased natural energy and to help boost concentration, the ability to pay attention, avoid distractions and stay alert throughout the day.
It is sometimes referred to as a much stronger version of caffeine, without the jittery side effects and may be beneficial for those that need to focus and concentrate for long periods of time.
In addition, the effects of this supplement may also include enhancing overall mood. Many users have reported increased feelings of confidence, motivation, reduced symptoms of depression and even euphoria when using this supplement. This effect may be more noticeable and longer lasting when taken in combination with PEA (phenylethylamine).
Hordenine is also considered to help to curb appetite and stimulate fat loss by potentially increasing the body’s metabolic rate, although there is a lack of human research studies to determine its efficacy.
Although these effects seem to be most beneficial for those that engage in exercise, a boost in metabolism increases the body’s ability to burn fat even in a resting state. Hordenine may also help to reduce the number of calories consumed throughout the day by controlling appetite which may also have positive effects in non-active people as well, making it a potentially great tool for those who are trying to lose weight.
Some users say that using Hordenine in combination (or Nootropic stack) with several other Nootropics like Aniracetam or Noopept or a superior source of choline like Alpha GPC (or others) may help increase its potential cognitive enhancing power and provide synergistic effects.
Side Effects of Hordenine
Hordenine, when taken by healthy adults in low dosages, has not been linked to serious adverse side effects and considered to be generally well tolerated.
Possible side effects that may occur include rapid heartbeat, inability to sleep, anxiety, dizziness, nausea, mood disruptions, stomach discomfort and potential hallucinations but seem to more likely when taking higher dosages. If you experience mild side effects, you may want to try lowering the dosage. If these side effects are serious, discontinue use immediately and seek medical attention.
Hordenine is considered to have stimulant effects which may adversely interact with medications, supplements or existing medical conditions.
Do not take this supplement if you are currently taking medications for high blood pressure or for any heart condition. This supplement may increase or decrease blood pressure and people who are sensitive to blood pressure changes should avoid this supplement entirely.
Consult with your doctor first for contraindications and a full list of medications or supplements that may interact with Hordenine.
Hordenine Dosage Guidelines
There is currently insufficient research to establish safe dosing ranges for Hordenine. The dosage guidelines listed are based on user reports and you should consult with your doctor first before taking this supplement to determine whether this supplement is right for you and to ensure the proper dosage based on your personal medical history.
User reviews suggest typically taking between 20 mg up to 50 mg per day in total. The higher end dosage can be divided up into 2-3 administrations of 20-30 mg over the course of the day but is not recommended to take too late in the day since it may disrupt normal sleep. Higher doses than listed above also raise the risk of potential side effects.
Individuals that are new to Hordenine should start at the lowest dosage range before gradually raising the dosage to gauge how this supplement personal affects you.
If you are interested in the effects and benefits of Hordenine related to exercise, the best course of action is to take it approximately 45 minutes prior to a workout. For those who intend to take it as a fat burning and weight loss aid, it is recommended to take it on an empty stomach earlier in the day and than again approximately 5-6 hrs later.
Hordenine is most known for its energy-boosting effects but it is also a well-regarded Nootropic supplement known to work well to promote focus, concentration, reduction in brain fog, motivation and drive.
There are also claims that Hordenine can promote fat loss and help control appetite in both athletes and non physically active individuals.
While there are adverse side effects to consider and this supplement needs to be taken with certain precautions, user reviews online often report that Hordenine produces increased feelings of well-being, pleasure and boosts energy for most people. On its own or in a Nootropic stack, you may want to consider adding Hordenine.
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