The Many Alpha GPC Supplement Benefits to Boost Your Brain

Alpha GPC is natural choline compound that is highly valued as a Nootropic and considered to be one of the safest and most effective brain supplements available. It is used by millions of people both on its own to potentiate impressive effects on many cognitive processes and in many Nootropic stacks, thought to act in synergy to increase their effects.

Type: Cholinergic Supplement
Used For: Memory, Focus, Reasoning, Learning Capacity, Attention, Mental Energy, Mood, Brain Health, Lucid dreaming, Cognitive Decline, Alzheimer’s Disease, Dementia
Half-Life: 4hrs-6hrs
Typical Dosage: 300 mg-1,200 mg per day
Some Possible Drug Interactions: Scopolamine
Supplement Interactions: No Known Interactions

What is Alpha GPC?

Alpha GPC (L-Alpha-glycerylphosphorylcholine) is a highly bioavailable and powerful cholinergic compound that occurs naturally but can also be supplemented. It acts as an enhanced version of the essential nutrient Choline that is closely related to the vitamin B family.

Alpha GPC High Choline SourceAs one of the more popular Nootropics for its effectiveness, safety profile and versatility, Alpha GPC is used both in combination with many other Nootropics or on its own for its purported powerful effects on enhancing memory, cognition and boosting energy.

Choline is a vitamin-B like nutrient, found naturally in small amounts in our body and from the breakdown of food sources such as meat, eggs, shellfish and wheat germ.

It plays very important roles in our energy levels and keeping our metabolism active. It is also vital for nerve function, so vital we couldn’t walk or even move without it. In addition, it is necessary for brain health and mental functions.

The body uses up choline sources more rapidly than the speed to which it can be replaced. It is estimated that approximately 90% of the adult North American population is choline deficient and does not get enough of this nutrient in their diet alone which may be due to some foods not actually digesting into the body.

Choline deficiencies may make you feel sluggish, give you muscle cramps, brain fog, difficulty recalling information, irritability, difficulty learning and keeping your balance and changes in your mood.

It is also believed that choline deficiencies or the risk of them, may come from a condition called “fatty liver” (FLD) which is an accumulation of fat in liver cells. This may be a result from over usage of alcohol, excessive fatty foods or any diseases related to metabolizing fats.

Alpha GPC is highly bioavailable, which means it targets the central nervous system fast and crosses the blood-brain barrier much more effectively than other sources of choline with methods of action that are thought to begin to work in as little as 20-30 minutes.

Choline is needed to synthesize the neurotransmitter Acetylcholine (ACh) and raise its level in the brain. This important chemical messenger is involved in the formation of memory, learning, attention and focus.

In addition, Alpha GPC is a choline-containing a type of phospholipid, a component of brain cell membranes in the cerebral cortex. This an area that is considered to carry out the highest levels of mental functioning and may be further involved in the protection of neurons in the brain and maintaining brain health.

In this article, we will examine what the benefits are of taking Alpha GPC, the effects of this supplement on cognitive processes, the safety profile and suggested dosage recommendation.

Alpha GPC and Choline Cognitive Benefits

Alpha GPC is a Nootropic supplement that is considered to be an effective cognitive enhancer and brain booster. Its most well-known benefit is for its positive effects on memory but it may also enhance several other cognitive functions.

One of the most important roles of Alpha GPC is to efficiently cross the blood-brain barrier and increase the available amount of choline which is needed to synthesize and raise the level of the neurotransmitter Acetylcholine (ACh). This is a brain chemical that is thought to be involved in several cognitive functions.

Acetylcholine is involved in memory formation, learning ability, focus, attention and many processes in regards to brain function. Alpha GPC is considered especially effective for enhancing short-term or working memory capacity where many anecdotal user reviews attest to this effect.

There are several studies indicating that Alpha GPC may be helpful in treating conditions of memory loss. This can range from conditions of age-related cognitive decline to Alzheimer’s Disease and may lead to improvements in attention and memory-related tasks.

In addition, raising levels of Acetylcholine synthesis may help improve logical thinking skills, our ability to remember and recall information or facts, have clearer thought processes, boost reasoning skills, articulate verbal skills, speed up our reaction to stimuli and enhance the ability to concentrate, focus and learn.

As we age, Acetylcholine (ACh) production declines. This brain chemical cannot cross the blood-barrier on its own and needs choline to produce it. It is important to get enough from your diet or by means of supplementation.

Another important effect of raising ACh levels in the brain is enhancing neuroplasticity. This means the ability for brain cells to form new connections through synapses in response to new experiences or new connections to information, logic, sensory stimuli and emotions.

We can call this a form of intelligence by potentially aiding the brain in the process of adapting to new experiences in order to thrive in new situations. This starts with healthy levels of Acetylcholine which is produced from choline. Alpha GPC is believed to produce better choline uptake than any other Choline supplement.

Additionally, this supplement helps increase blood circulation to the brain. This results in better delivery of oxygen and improved glucose metabolism, the brains main energy source. This effect may lead to users experiencing more clarity of thought, mental energy and a longer attention span.

Alpha GPC and Brain Health

Alpha GPC has been suggested to positively support the maintenance of overall brain health by acting as a neuroprotectant, repairing damaged cell membranes and encouraging growth, efficiency and communication of neurons.

This compound is a phospholipid (lecithin) which is the most abundant type of lipid component in cell membranes and functions to protect the cell from its surroundings. This may help support the development of new cell membranes and repair previous damage which is an important anti-aging benefit.

In studies, age-related cognitive decline has been linked to many neurons with degenerate cell membranes. If there is an insufficient amount of choline present, it will cannibalize the choline present in cell membranes to produce Acetylcholine.

Alpha GPC makes more choline available and may contribute to solving this problem and the amount of reserves in the cells. Through this, it may improve the communication between the neurons and help with age-related cognitive decline. It may even help to prevent cognitive impairment. This effect is often described by users as the ability to think faster.

Alpha GPC is not currently an approved drug by the FDA to treat or prevent any conditions and is only available as a health supplement. The research on the benefits of Alpha GPC choline for cognitive improvement is promising but more research is needed.

Alpha GPC Stacks

Alpha GPC has a fast acting mechanism of action for delivering choline, a nutrient needed to produce Acetylcholine, the neurotransmitter that is thought to be responsible for many of the positive effects of Racetam Nootropics which includes Aniracetam, Pramiracetam, Oxiracetam, Piracetam and even Noopept and may support their mechanisms of action when used in stacks.

The most common side effect of Racetams are headaches which may be due, in most cases when Acetylcholine receptors need additional choline when amounts are not available.

This is why it is believed that when using these types of Nootropics, stacking them with a choline supplement such as Alpha GPC may alleviate this problem and even promote synergistic effects.

Side Effects

Alpha GPC is considered to be a safe, well-tolerated and non-toxic supplement. Side effects are rare and if occur, are mostly associated with higher than recommended doses.

The associated side effects of Alpha GPC are typically fairly mild including nausea, headaches, fatigue, nervousness, skin rash and insomnia. Simply lowering the dose may alleviate these side effects or in some cases discontinue use for a few days.

Alpha GPC may provide an energy boost and it is recommended to not take this supplement too late in the day to avoid the potential of having difficulty falling asleep.

More serious side effects reported are rare but include dizziness, confusion or lowered blood pressure. If this occurs, discontinue use and seek medical advice right away.

Alpha GPC is not recommended for pregnant or nursing women. In addition, children should not take this supplement simply due to lack of test information.


Alpha GPC is water soluble and a fast acting supplement, which means you can use less to get its benefits. Many experts suggest a dosage range between 600 mg-1,200 mg daily which can be divided into two administrations, 300 mg once in the morning and once in the early afternoon may be sufficient to achieve results.

When starting on any new supplement is it always recommended to start at the lower dosage range to determine how it will affect you and what works best for you before increasing the dosage.

In some clinical applications, 1,200 mg may be considered the appropriate dosage amount for patients with Alzheimer’s or other forms of cognitive decline. It is advised to speak to your doctor first before using this supplement or any other Nootropic if you are currently taking medications or have medical conditions.

Alpha GPC may not interact well with Scopolamine (Transderm Scop) which seems to work by blocking Acetylcholine. This is the opposite method of action of Alpha GPC. It is unclear if it decreases the benefits of this drug and therefore it is recommended to avoid combining them.

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