What Are the Best Nootropics for Energy & Motivation?

Energy and especially sustainable energy is one of the most important factors in optimally and comfortably performing both mentally and physically throughout the day and often goes hand in hand with our level of motivation and productivity.

The Best Nootropic Supplements for Energy and MotivationEveryone gets energized differently but we are all utilizing energy every moment of the day. The brain alone uses more energy than any other organ, taken up 20% of the entire body’s haul.

When we lack basic energy, it negatively affects our cognitive capacity, mental drive, mood, memory, ability to focus, creativity and everything else we would like to be working optimally throughout the day.

While we are very accustomed to grabbing a cup of the most widely used stimulant in the world, caffeine or even grabbing an energy drink when we feel a depletion of energy, Nootropic use for this purpose continues to gain much popularity as more and more individuals are looking for ways to help boost sustainable overall energy and mental stamina and may find Nootropics very helpful tools.

While mental fatigue and low motivational states can have several different causes, Nootropics also work in various ways such as providing energy sources to brain cells or working to stimulate the production, release and uptake of key neurotransmitters involved in energy, feelings of positivity or motivation.

So what are the best Nootropics for energy and motivation to consider? Here is a list with brief summaries and links to more extensive information, safety profiles and dosage guidelines.

Top Nootropics For Energy and Motivation


1. Acetyl L-Carnitine

Type: Natural Nootropic
Used For: Memory, Mental Energy, Focus, Clarity, Cognitive Function, Anti-Aging, Athletic Performance and more.

Acetyl-L-Carnitine Summary


Acetyl-l-Carnitine or more known as ALCAR, is a derivative of an amino acid. It is a more bioavailable form of carnitine with the capability of easily crossing the blood-brain barrier, acting within the brain itself, an action that carnitine cannot do. The effects of this supplement are related to enhancing memory, concentration, increasing both physical and mental energy and boosting mood.

ALCAR acts as a precursor to the neurotransmitter Acetylcholine, a powerful brain chemical influencing several cognitive processes such as memory formation and consolidation, learning capacity, focus and attention. It is also thought to increase levels of other neurotransmitters such as Serotonin and Noradrenaline highly involved in mood and energy.

In addition, this supplement is considered to have potent antioxidant properties, acting to repair and prevent damage to brain cells caused by free radicals damage and helping to protect the brain by eliminating toxins.

2. Modafinil

Type: Eugeroic Drug
Used For: Narcolepsy, Obstructive Sleep Apnea, Shift Work Sleep Disorder, Daytime Sleep Disorders OFF LABEL: Cognitive Performance, Focus, Energy, Wakefulness, Processing Speed, Motivation, Mental Acuity, Learning Capacity, ADD/ADHD, Productivity, Memory

Modafinil Summary


Modafinil is a eugeroic drug (meaning “good arousal”) or those that promote wakefulness and alertness. It was developed for the treatment of sleep disorders and used off-label by healthy people as a “smart drug” or cognitive enhancer for its ability to prevent daytime fatigue, especially in those that lack sleep and to enhance focused alertness, increase motivation and improve reaction time.

Uniquely and different to stimulants which act to target the entire nervous system to temporarily boost overall psychomotor activity, eugeroics like Modafinil, target certain neurotransmitters and their receptors which can lead to specifically producing mental arousal and enhancing concentration while mitigating the highs and lows associated with amphetamines and other stimulants.

Modafinil is believed to stimulate the orexin system in the brain that is responsible for regulating wakefulness, which also elevates the production of histamines and other neurochemicals involved in wakefulness and alertness. It is also thought to indirectly and more gradually boost the level of available Dopamine in the brain, a neurotransmitter associated with mood, focus and motivation.

3. Adrafinil

Type: Stimulant/Eugeroic Compound
Used For: Mental Drive, Energy, Wakefulness, Alertness, Focus, Attentiveness, Mood, Sleep Disorders, Mental Performance, Memory Enhancement, Motivation

Adrafinil Summary


Adrafinil is a wakefulness and alertness promoting eugeroic compound and prodrug to the cognitive enhancer Modafinil, meaning it converts in the body to Modafinil but does not require a prescription to buy. As part of the class of eugeroics, it is a unique stimulant that can reduce daytime fatigue and boost energy without causing side effects that are typically associated with stimulants.

In addition, it is also considered to be an effective Nootropic supplement that may positively affect motivation, boost focus and enhance cognition with pharmacological actions and effects that are almost identical to Modafinil.

As such, it is thought to stimulate the brains hypocretin/orexin system which is key to wakefulness and arousal. This action is also thought to replicate the energy and alertness boosting effects of adrenaline and modulate the levels of important neurotransmitters Norepinephrine and Dopamine associated with mood, mental drive and the brain’s ability to pay attention.

4. Phenylpiracetam

Type: Racetam Nootropic
Used For: Memory Enhancement, Learning Capacity, Focus, Energy, Stamina, Mood Enhancement, Athletic Performance and more.

Phenylpiracetam Summary


Phenylpiracetam is a highly potent and faster acting member of the Racetam family of Nootropics. It is a modified version of the first Nootropic ever synthesized over 50 years ago, Piracetam and considered a powerful compound to help combat physical and mental fatigue and boost cognition, memory, learning capacity, focus and concentration.

This Nootropic has “clean” stimulating and motivating like properties. It is thought to increase blood flow to the brain, allowing for more oxygen and nutrient uptake into brain cells helping to boost cognition, alertness and mood.

It may also increase the density of receptors for several important neurotransmitters that are associated with memory formation, decision-making capability, attention and certain neurochemicals that when levels are higher, help decrease symptoms of anxiety and depression.

5. Sulbutiamine

Type: Nootropic Supplement/Vitamin B Derivative
Used For: Energy, Mood, Memory, Cognitive Function, Mental Stamina, Focus, Anxiety, Motivation and more.

Sulbutiamine Summary


Sulbutiamine is a synthesized version of vitamin B1 (thiamine) that is capable of crossing the blood-brain barrier easily. It is supplemented for its Nootropic effects and used to promote mental energy, enhanced cognitive function, boost mood and increase motivation.

This highly fat-soluble Nootropic quickly and broadly circulates in both the body and brain, positively influencing dopamine receptors and the cholinergic and glutamatergic systems that are involved in memory, focus and mood. It is also thought to help carbohydrates convert into energy with more ease.

Feelings of depression, poor cognition, problems paying attention and low mood have all been linked as plausible results associated with a lack of Vitamin b1 but if you are not deficient, this supplement may still be beneficial since it seems to demonstrate profound positive effects, even in those that are healthy.

6. Noopept

Type: Peptide/Cognitive Enhancer
Used For: Memory Enhancement, Focus, Cognitive Performance, Mental Energy, Brain Fog, Mood, Anxiety, Depression, Brain Health

Noopept Summary


Noopept is considered to be one of the most effective and fastest acting Nootropics available on the market. The effects of this compound can typically be noticed within 15 minutes and it is most commonly used to enhance mental performance and boost cognition.

While a number of studies indicate that it can increase memory and learning abilities, users suggest that it also has positive mood-related effects, helping symptoms that are often associated with depression such as an anxiolytic effect (reducing anxiousness or anxiety), clearing brain fog and greatly boosting motivation.

This Nootropic is thought to stimulate receptors in the brain involved in several mental processes and mood. It also acts as a neuroprotectant, meaning it helps keep neurons in the brain healthy and may even contribute to increases connections within the brain that may encourage the experienced benefits to be more sustainable long-term.

7. Tyrosine

Type: Amino Acid/Natural
Used For: Focus, Motivation, Mental Clarity, Mood, Stress, Energy, Alertness, Chronic Fatigue Syndrome, Physical Performance and more.

Tyrosine Summary


L-Tyrosine (also known as Tyrosine) is one of many standard amino acids that are used by the cells in our body to build proteins and influence the production of neurotransmitters that are involved in cognition and mood.

Synthesized from another amino acid, Phenylalanine, it is a building block to several important brain chemicals such as Dopamine, Epinephrine and Norepinephrine, catecholamines that are highly related to mood, the brains ability to focus, resilience to stress and associated with mental drive and motivation.

Increasing levels of these neurotransmitters may influence a wide range of enhanced mental processes and aspects of mood, especially when under conditions such as lack of sleep, high stress and prolonged working schedules, where supplementing Tyrosine may be very helpful.

8. Oxiracetam

Type: Racetam Nootropic
Used For: Memory Enhancement, Concentration, Learning, Enhanced Analytical Thinking, Mental Performance, Mental Energy and more.

Oxiracetam Summary


Oxiracetam is considered a safe and effective true cognitive enhancing agent belonging to the Racetam family of Nootropics. It is believed to positively affect a broad range of cognitive processes from attention span, focus, concentration and learning to technical/logical thinking with countless studies confirming its positive effects on memory performance.

It is thought to influence and raise the levels of two important neurotransmitters Acetylcholine and Glutamate, highly associated with memory formation, learning and processing thoughts.

Increasing the activity of excitatory neurotransmitters, Oxiracetam may also have a mild stimulant-like effect, described by users as additionally boosting mental energy and levels of productivity and is especially noted to be helpful when needing to focus intensely for long periods of time.

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