Aniracetam Nootropic Review- Cognitive and Mood Effects

Aniracetam is a member of the racetam family of Nootropic supplements that may boost memory, focus, mood and reduce feelings of anxiety. It is regarded to have a low occurrence of negative side effects and is popularly considered a powerful cognitive and mood-enhancing compound.

Type: Racetam Nootropic
Used For: Focus, Cognitive Function, Memory Enhancement, Learning Capacity, Anxiety, Depression, Cognitive Decline, Alzheimer’s Disease
Half-Life: 1hr-3hrs
Typical Dosage: 500 mg-1,500 mg per day
Drug Interactions: No Known Interactions
Supplement Interactions: No known Interactions

What is Aniracetam?

Aniracetam is a Nootropic compound or smart drug that was developed by the Hoffmann-La Roche company in the 1970s that exhibits anti-anxiety like effects and may enhance memory, focus and aspects of mood. It belongs to the Racetam family of Nootropics which are the most popularly used class of cognitive enhancers to date.

What is Aniracetam?Racetams are a chemical class of Nootropics that share a common pyrrolidone structure. They are believed to work by modulating important neurotransmitters such as Acetylcholine and Glutamate.

These are chemical messengers in the brain that play important roles in vital cognitive functions such as memory, learning capacity, focus, thinking skills, energy levels and mood. Additionally, Racetams are thought to positively affect some of the fundamental components of brain health.

The effects of Aniracetam have been well documented since this Nootropic drug has been around for over 45 years. It is a modified version of Piracetam, the first Nootropic ever synthesized and anecdotally believed to be up to 10 times more potent.

It is fat-soluble (lipophilic) compound, which indicates a faster acting Nootropic drug but it also appears to rapidly break down in the body. This gives it a shorter half-life than other Racetams, so multiple dosing throughout the day may be needed.

Based on clinical research reviews, it is suggested that this compound is non-toxic and has a low risk of negative side effects when taken appropriately. It is popularly taken off-label as a “smart drug” noted for its positive effects on various cognitive functions like memory, attention, focus, verbal fluidity and vigilance. In addition, it is most commonly touted for its unique effects as an anxiolytic (reduced feelings of anxiety) and as a mood enhancer.

Aniracetam is also available as a prescriptive drug in Europe and parts of Asia under the brand names Referan, Draganon, Ampamet, Memodrin and Sarpul where it has been used clinically for age-related memory loss, in the treatment of Alzheimer’s disease and to relieve anxiety and depression following a stroke.

In the United States, Canada and Australia, Aniracetam does not require a prescription to purchase. In other countries, there may be some restrictions on its sale or importation. It’s a good idea to check the current laws in your country before buying it.

If you are interested in trying Aniracetam, it is important to first understand how this Nootropic works, its reported benefits and user experiences, the risk of side effects and suggested dosage guidelines.

Aniracetam Cognitive Benefits, Effects and Experiences

Aniracetam is known as a cognitive enhancer and largely considered to lack prevalent side effects making this Nootropic extremely popular.

Most users describe the benefits and experience of Aniracetam as enhancing memory, giving them greater mental energy, motivation, increased mental clarity and significant improvements in the ability to focus and concentrate. In addition, reduction in shyness, social anxiety and heightened sensory perception have also been reported.

Aniracetam is believed to increase the synaptic release of an important chemical messenger in the brain, Acetylcholine (ACh) by binding to these receptors and inhibiting desensitization. This may result in raising the level of this important neurotransmitter that is involved in memory formation, learning, focus and speed of mental processing.

This may explain why many users report a heightened ability to concentrate and focus, absorbing information is easier and thoughts are much clearer when using Aniracetam.

In addition, cognitive decline is associated with aging in the brain which involves the decrease in levels of several neurotransmitters including Acetylcholine (ACh). By raising its availability in the brain, Aniracetam may help slow down the potential for age-related cognitive decline and may be useful for older individuals to boost cognitive ability with continued use.

Boosting the cholinergic system (Acetylcholine receptor activity) has also been linked to heightened sensory perception. Users have reported heightened visual and audio perception where listening to music is more pleasurable and colors are more vivid.

Another believed mechanism of action of Aniracetam is slowing the breakdown of the important neurotransmitter Glutamate, by modulating AMPA receptors in the brain which may lead to increase its availability.

Glutamate is a chemical used by nerve cells to send signals to other cells and thought to play an important role in the linking of circuits for memory, learningperception. It is also believed to be the most important transmitter for normal brain function.

AMPA receptors for Glutamate are thought to specialize in fast excitation and are highly involved in many forms of synaptic plasticity such as (LTP) Long-Term Potentiation (synaptic strength) which underlines learning and memory.

Studies have shown that Aniracetam improves both short-term and long-term memory. This effect has been reported by many users as the ability to remember the smallest details, facts, conversations, and figures, although this effect may vary from person to person.

Additionally, stimulation of AMPA receptors is believed to increase the release of Norepinephrine in the brain which promotes increased alertness, reaction time, attention and energy.

There is also some evidence suggesting that Aniracetam may increase the communication between the hemispheres in the brain which may play a primarily important role in some of its most sought out Nootropic effects.

This may encourage a better flow of information and the ability to connect thoughts which may lead to experiencing an increase in attention to detail, the formation of ideas and a better ability to make resourceful decisions. Some users describe the experience of this effect as increased reasoning and holistic thinking.

Finally, in research trials, Aniracetam has been observed to have neuroprotective properties that may help protect your brain cells from damage caused by external sources such as excessive alcohol consumption. In some cases, it may even contribute to the reversal of this damage.

Aniracetam Effects on Mood

Uniquely, Aniracetam is the only Nootropic drug among the Racetam class which also includes (Oxiracetam, Piracetam, Phenylpiracetam Pramiracetam, Coluracetam and others) that has highly notable positive effects on mood enhancement, depression, relaxation and social anxiety.

Aniracetam seems to exhibit effects on Dopamine and Serotonin in the brain by binding to receptors and inhibiting their breakdown. This may raise the availability of these two important neurotransmitters that are highly linked to mood and involved in positive feelings, pleasure, enjoyment, motivation, relaxation, happiness and sleep cycles.

Most users have described this effect as promoting a sense of well being or a natural and focused sense of calmness, relieving symptoms of stress, depression and enhancing motivation and confidence in situations that would otherwise cause anxiousness.

Not all users experience the same mood effects of Aniracetam. Others have reported this Nootropic makes them agitated, irritable and anxious. This may be due to dosage and can also depend on many different factors but it is unclear exactly why people experience these effects.

The uses for Aniracetam on depression, anxiety and mood enhancement have been used clinically in Japan in the treatment following cerebral strokes and in patients with cognitive deficits.

Some Nootropic users have noted to experiment with stacking combinations and cycling methods to improve these effects and find what works best for them.

The Research and Medical Uses of Aniracetam

The information above comes from anecdotal user reviews describing the effects of using Aniracetam as a “smart drug” which has been compiled over decades since this Nootropic drug has been available.

Most of the studies on the efficacy of Aniracetam comes from research on individuals suffering from cognitive impairments or temporary mental decline in healthy adults caused by conditions such as low oxygen to tissues (hypoxia).

Research supports the positive effects of this compound on memory and learning but only under certain conditions when a cognitive deficit is present. It has also been observed to improve emotional states and motor functionality after three months of use and enhance cognitive performance within six months. This may be promising for people suffering from types of dementia.

Aniracetam has been therapeutically used in the treatment of many conditions around the world. Although it is not an approved drug by the FDA in the United States to prevent or treat any conditions, doctors may prescribe it to patients where it is suited to potentially help with certain medical conditions like:

  • Cognitive Disorders in the Elderly
  • Cognitive Impairment
  • Senile Dementia
  • ADHD (Attention Deficit Hyperactive Disorder)
  • Personality Disorders
  • Anxiety and Depression following Cerebral Ischemia
  • Vertigo and Motion Sickness
  • Psychological problems due to moderate Brain Decay

Many of these medical uses have been clinically studied, however, it is highly advised to consult with your doctor first before using Aniracetam if you have been diagnosed with any these medical conditions or want to use it for therapeutic purposes to be sure that it is right for you.

Aniracetam Side Effects

Aniracetam is considered to be well-tolerated by most people and believed to have no detected liver toxicity. Dangerous side effects have not been reported when using this Nootropic at the proper dosages.

In rare cases, mild side effects have been reported that may be mostly due to high doses, nootropic combinations or related to individual tolerance to this Nootropic which includes headaches, nausea, anxiety, nervousness, skin rash, low mood and fatigue.

Headaches are the most common reported side effect when using all Racetam Nootropic supplements. This may be attributed to a potential choline deficiency or the amount of available choline used to produce Acetylcholine.

To avoid this side effect, it is recommended by several nootropic guides to use Aniracetam in combination with a choline source such as Alpha GPC or CDP Choline.

In addition, it is suggested to not take Aniracetam too late in the day since it may interfere with sleep cycles.

“Brain fog” when initially using Aniracetam may occur. Exactly why this may potentially happen is unclear. Theoretically, this may be due to the modulation of Acetylcholine. In many user reports, it is suggested that this may pass after a few days of use, however, if this occurs, it is suggested to try lowering the dosage and if it continues, discontinue use.

The intoxicating effects of alcohol can be increased when in combination with Aniracetam and may affect you in different ways such as increased impaired motor function or behavioral control and should be avoided.

Do not take Aniracetam if you are pregnant, nursing or planning for pregnancy. There isn’t enough research to make a conclusion about the safety of this drug.

Aniracetam is thought to affect Serotonin. Anti-depressant medications in combination with Aniracetam could increase the risk of side effects. In addition, Aniracetam may have interactions with other drugs. If you are currently taking medications, you should consult with your doctor first before using this drug to ensure it will not interact with any medications you are taking.

Aniracetam Dosage

The average typical daily dosage range of Aniracetam is between 500mg-1500mg or less if using it in combination with other Nootropics.

The doses can be divided into two equal administrations preferably once in the morning and once in the early afternoon to avoid any sleep disturbances. The average half-life of this Nootropic is around 3 hours, which is why it is suggested to divide the doses.

Do not take an additional (double up) dose if you miss one, just simply skip it. Although Aniracetam is considered to have a low risk of toxicity, taking too much can lead to negative side effects.

It is recommended to always stay within the lowest dose available when starting on any new Nootropic supplement. This helps you gauge your body’s effect and find what works best for you before raising the dosage.

Aniracetam is a fat-soluble agent. For faster absorption, it should be taken with a source of fat such as coconut oil, olive oil or with a meal containing fat.

These are just dosage guidelines. It is always best to consult with a doctor first before using any new supplement to ensure it is right for you based on your own personal medical profile.

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  1. Tian Y, Zhang JJ, Feng SD, Zhang ZJ, Chen Y. Pharmacokinetics and bioequivalence study of aniracetam after single-dose administration in healthy Chinese male volunteers. Arzneimittelforschung. 2008;58(10):497-500. doi: 10.1055/s-0031-1296547.[source]
  2. Gabryel B, Chalimoniuk M, Małecki A, Strosznajder J. Effect of aniracetam on phosphatidylinositol transfer protein alpha in cytosolic and plasma membrane fractions of astrocytes subjected to simulated ischemia in vitro. Pharmacol Rep. 2005 Sep-Oct;57(5):664-9.[source]
  3.  Wijayawardhane .1, Shonesy B.C., Vaglenova J., Vaithianathan T., Carpenter M., Breese C.R., Dityatev A., Suppiramaniam V. “Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission.” Neurobiology of Disease 2007 Jun;26(3):696-706. [source]
  4. Isaacson J.S., Nicoll R. A. “Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus” Proceedings of the National Academy of Sciences in the United States of America vol. 88, pp. 10936-10940, December 1991[source]
  5. Lee CR, Benfield P. Aniracetam. An overview of its pharmacodynamic and pharmacokinetic properties, and a review of its therapeutic potential in senile cognitive disorders. Drugs Aging. 1994 Mar;4(3):257-73. Review.[source]
  6. Nakamura K, Kurasawa M. Serotonergic mechanisms involved in the attentional and vigilance task performance of rats and the palliative action of aniracetam. Naunyn Schmiedebergs Arch Pharmacol. 2000 May;361(5):521-8.[source]
  7. Ouchi Y, Kakiuchi T, Okada H, Nishiyama S, Tsukada H. The effect of aniracetam on cerebral glucose metabolism in rats after lesioning of the basal forebrain measured by PET. J Neurol Sci. 1999 Mar 15;164(1):7-12.[source]
  8.  Shirane M, Nakamura K. Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. Brain Res. 2001 Oct 19;916(1-2):211-21. Erratum in: Brain Res 2002 Feb 1;926(1-2):197.[source]
  9. Isaacson JS, Nicoll RA. Aniracetam reduces glutamate receptor desensitization and slows the decay of fast excitatory synaptic currents in the hippocampus. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10936-4.[source]
  10. Pittaluga A, Bonfanti A, Arvigo D, Raiteri M. Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):272-9.[source]
  11. Nakamura K, Kurasawa M. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43.[source]
  12. Human Pharmacokinetics of Aniracetam[source]
  13. Cumin R, Bandle EF, Gamzu E, Haefely WE. Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents. Psychopharmacology (Berl). 1982;78(2):104-11.[source]
  14. Nakamura K, Tanaka Y. Antidepressant-like effects of aniracetam in aged rats and its mode of action. Psychopharmacology (Berl). 2001 Nov;158(2):205-12.[source]
  15. Tang CM, Shi QY, Katchman A, Lynch G. Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam. Science. 1991 Oct 11;254(5029):288-90.[source]
  16. Zhao X, Kuryatov A, Lindstrom JM, Yeh JZ, Narahashi T. Nootropic drug modulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons. Mol Pharmacol. 2001 Apr;59(4):674-83.[source]
  17. O’Neill MJ, Bleakman D, Zimmerman DM, Nisenbaum ES. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord. 2004 Jun;3(3):181-94. Review.[source]
  18. Vaglenova J, Pandiella N, Wijayawardhane N, Vaithianathan T, Birru S, Breese C, Suppiramaniam V, Randal C. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology. 2008 Apr;33(5):1071-83. Epub 2007 Jul 4.[source]
  19. Gabryel B, Chalimoniuk M, Małecki A, Strosznajder J. Effect of aniracetam on phosphatidylinositol transfer protein alpha in cytosolic and plasma membrane fractions of astrocytes subjected to simulated ischemia in vitro. Pharmacol Rep. 2005 Sep-Oct;57(5):664-9.[source]
  20. Galeotti N, Ghelardini C, Bartolini A. Piracetam and aniracetam antagonism of centrally active drug-induced antinociception. Pharmacol Biochem Behav. 1996 Apr;53(4):943-50.[source]
  21. Staubli U, Ambros-Ingerson J, Lynch G. Receptor changes and LTP: an analysis using aniracetam, a drug that reversibly modifies glutamate (AMPA) receptors. Hippocampus. 1992 Jan;2(1):49-57.[source]
  22. Kraaier V, van Huffelen AC, Wieneke GH. The hyperventilation-induced ischaemia model in human neuropharmacology: neurophysiological and psychometric studies of aniracetam and 3-OH aniracetam. Eur J Clin Pharmacol. 1989;36(6):605-11. [source]
  23. Sourander LB, Portin R, Mölsä P, Lahdes A, Rinne UK. Senile dementia of the Alzheimer type treated with aniracetam: a new nootropic agent. Psychopharmacology (Berl). 1987;91(1):90-5.[source]
  24.  Petkov VD, Mosharrof AH, Milenkov B, Enev V. Learning and memory effects of four newly-synthesized aniracetam analogues. Acta Physiol Pharmacol Bulg. 1989;15(2):18-27.[source]
  25. Petkov VD, Grahovska T, Petkov VV, Konstantinova E, Stancheva S. Changes in the brain biogenic monoamines of rats, induced by piracetam and aniracetam. ActaPhysiol Pharmacol Bulg. 1984;10(4):6-15.[source]
  26. Journal of Physiology (1990), 424, pp. 533-543 533 With 5 figures ALLOSTERIC POTENTIATION OF QUISQUALATE RECEPTORS BY A NOOTROPIC DRUG ANIRACETAM[source]
  27. Lee, C.R. & Benfield, P. Drugs & Aging (1994) 4: 257.[source]
  28. Yoshii M, Watabe S. Enhancement of neuronal calcium channel currents by the nootropic agent, nefiracetam (DM-9384), in NG108-15 cells. Brain Res. 1994 Apr 11;642(1-2):123-31.[source]
  29. Shirane M, Nakamura K. Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. Brain Res. 2001 Oct 19;916(1-2):211-21. Erratum in: Brain Res 2002 Feb 1;926(1-2):197[source]
  30. Vaglenova J, Pandiella N, Wijayawardhane N, Vaithianathan T, Birru S, Breese C, Suppiramaniam V, Randal C. Aniracetam reversed learning and memory deficits following prenatal ethanol exposure by modulating functions of synaptic AMPA receptors. Neuropsychopharmacology.[source]
  31. Lauterborn JC, Pineda E, Chen LY, Ramirez EA, Lynch G, Gall CM. Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2009 Mar 3;159(1):283-95. doi: 10.1016/j.neuroscience.2008.12.018. Epub 2008 Dec 24.[source]
  32. National Center for Biotechnology Information. PubChem Compound Database; CID=2196, (accessed Apr. 16, 2018).[source]

One Comment

  1. Kaan April 12, 2018 at 6:36 pm - Reply

    Hey, this is cheaper than pharmaceutical pills if it delivers everything it says it does..

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