Coluracetam Nootropic Benefits, Experience & Dosage

Coluracetam

• Boosts Acetylcholine Activity
• Supports Memory
• May Enhance Mood & Vision

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Coluracetam is a newer member to the Racetam family of Nootropics with similar cognitive enhancing properties typical to this class but its key benefits may lay particularly in its helpfulness in the treatment of major depressive disorder with generalized anxiety.

Type: Racetam Nootropic
Used For: Mood Enhancement, Focus, Depression, Anxiety, Enhancing Cognition, Memory, Improving Vision
Half-Life: 2hrs-3hrs
Typical Dosage: 20 mg-80 mg per day
Drug Interactions: Unknown (Limited Research)
Supplement Interactions: Unknown (Limited Research)

What is Coluracetam?


Coluracetam (BCI-540 formerly MKC-231) belongs to the group of Racetam Nootropics and is a derivative of Piracetam. It is a synthetically produced compound that is thought to be structured and work in a uniquely different way from other Racetams but may share certain similar effects. It is generally recognized for enhancing memory, cognitive function and touted for its positive effects on anxiety and depression.

What is Coluracetam Used For?It was originally developed in Japan by Mitsubishi Tanabe Pharma Corporation in hopes to treat Alzheimer’s Disease and was only registered in 2005. In clinical trials, the drug failed to reach the endpoints and the patent was then transferred to Braincells Inc. a California based biopharmaceutical company for further testing on its effects.

The results of these clinical trials suggested that Coluracetam is a promising potential treatment for MDD (major depressive disorder) and for generalized anxiety.

In addition, a small amount of evidence suggests Coluracetam may affect areas of the brain that are linked to visual processing, enhancing colors, shapes and improving eyesight. Future potential medical use for optical and retinal nerve damage may be a possibility. This is in fact how this Nootropic got its name.

As a fairly new member to the Racetam class of Nootropics, its distribution is still very limited at this time, yet this supplement has still been steadily gaining in popularity with thousands of individuals noting positive results.

This article will examine the benefits associated with Coluracetam, how it works, potential side effects and dosage guidelines.

Coluracetam Benefits & Effects


The most promising benefits of Coluracetam are related to boosting both working and long-term memory, reducing symptoms of anxiety and depression and enhancing color vision.

Currently, there has been a limited amount of human testing on Coluracetam which may due to how new this compound is and evidence of the possible benefits of this compound can only be deduced from tests conducted on rats.

Anecdotally, there have been many users online reporting the positive effects of Coluracetam, noting they experience reduced levels of anxiety and stress, improvements in vision and powerful effects on cognitive functions when this Nootropic, especially when taken in combination with other racetams.

Coluracetam is a derivative of Piracetam, the first Racetam ever developed and belongs to the wider Racetam family of Nootropics which are believed to modulate Acetylcholine, an important neurotransmitter which is thought to be highly involved in memory formation, learning capacity, attention and focus.

However, Coluracetam is unique in its method of action. Choline is needed to synthesize Acetylcholine (Ach) and this Nootropic is thought to help raise levels of this brain chemical by enhancing the uptake of Choline in the neurons (even if they are impaired) rather than stimulating the sensitivity of ACh receptors.

This may lead to improvements in the level and efficiency of this nutrients use throughout the body and the brain. Specifically, Coluracetam is thought to interact with the process of HACU (High-Affinity Choline Uptake) which targets choline absorption into the neurons.

Increasing the availability of choline means the neurons have the necessary amount to synthesize Acetylcholine and these actions are thought to lead to positive effects on cognition, alertness, concentration and memory.

In animal testing on rats, Coluracetam has shown to improve memory. These improvements were also observed to continue even when the administration of this substance was discontinued three days prior, leading to an indication that it may have some kind of long-term positive effect or restoration on memory abilities.

In addition, Coluracetam may improve mood, relieving symptoms of depression and quieting anxiety by enhancing choline uptake. Deficiencies of this nutrient have been associated with negative changes in mood and mood disorders. This Nootropic may also help improve AMPA potentiation which may increase the effectiveness of Glutamate, a neurotransmitter associated with synaptic plasticity or helping neurons make new connections.

There is no evidence to explain how this process exactly works but in a trial conducted by Braincells Inc, Coluracetam had shown to be a promising agent in the treatment of MDD (Major Depressive Disorder) with generalized anxiety, with 36% of participants showing improvements after two doses of 80mg each, especially pronounced in those that have previously found no relief when using standard anti-depressants.

Finally, this supplement has been associated with enhancing color vision, described by users as a sharper vision, where it may affect the area of the brain responsible for visual processing.

Coluracetam

• Boosts Acetylcholine Activity
• Supports Memory
• May Enhance Mood & Vision

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Coluracetam

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Phenylpiracetam

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Piracetam

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Potential Coluracetam Side Effects


At the moment, Coluracetam has limited history and research to determine its toxicity levels but seems to have a similar safety profile to most other popular Racetams.

Braincells corporation has not reported any negative effects thus far when using this compound up to a total daily dosage of 240 mg.

Headaches are a commonly reported side effect when using Racetams in general and may potentially occur. You may want to consider stacking Coluracetam with CentrophenoxineAlpha GPC or CDP Choline which may help to alleviate this problem.

Coluracetam Suggested Dosage


Due to the newness of this Nootropic and its research being conducted on rats and there are no recommended dosage guidelines for humans. Anecdotal user reports suggest dosing between 20mg- 80mg per day in total. At the higher end, the dosage can be divided into three to four administrations.

It is recommended to always stay within the lowest dose available when starting on any new Nootropic supplement. This helps you gauge your body’s effect and find what works best for you before raising the dosage. In this case, starting at 20mg daily may be sufficient to give you positive effects and is especially recommended if you are new to Nootropics.

Some more experienced Racetam Nootropic users may find 200mg per day in total to be adequate.

It is always a good idea to consult your doctor first before using supplements and especially when you are already diagnosed with conditions.

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  1. Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1027-35. doi: 10.1007/s00702-008-0048-1. Epub 2008 Apr 30.[source]
  2. Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. doi: 10.1007/s00702-008-0053-4. Epub 2008 May 7.[source]
  3. Murai S, Saito H, Abe E, Masuda Y, Odashima J, Itoh T. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. J Neural Transm Gen Sect. 1994;98(1):1-13.[source]
  4. BrainCells Inc. Announces Results from Exploratory Phase 2a Trial of BCI-540 in Depression With Anxiety[source]
  5. Ray B, Bailey JA, Simon JR, Lahiri DK. High-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in neuronal cultures for mechanistic and drug discovery studies. Curr Protoc Neurosci. 2012 Jul;Chapter 7:Unit 7.23. doi: 10.1002/0471142301.ns0723s60.[source]
  6. Akaike A, Maeda T, Kaneko S, Tamura Y. Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons. Jpn J Pharmacol. 1998 Feb;76(2):219-22.[source]
  7. National Center for Biotechnology Information. PubChem Compound Database; CID=214346, https://pubchem.ncbi.nlm.nih.gov/compound/214346 (accessed Apr. 16, 2018).[source]

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