Phenylpiracetam Nootropic Review: Cognitive, Mood and Energy Effects

Phenylpiracetam

• Enhances Cognitive Performance
• Boosts Attention & Focus
• Promotes Energy & Productivity

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Phenylpiracetam is a powerful member of the racetam family of Nootropics with stimulant and cognitive enhancing effects that may boost memory, cognition, physical performance and mood.

Type: Racetam Nootropic
Used For: Memory Enhancement, Learning Capacity, Focus, Energy, Stamina, Mood Enhancement, Athletic Performance, Depression, Anxiety, Stroke, Dementia
Half-Life: 3hrs-5hrs
Typical Dosage: 200 mg-300 mg per day
Drug Interactions: No Known Interactions
Supplement Interactions: No Known Interactions

What is Phenylpiracetam?


Phenylpiracetam is one of the most powerful Nootropic agents or smart drugs belonging to the family of Racetams. It is commonly used to promote physical output, boost brain power and encourage states of productivity.

Phenylpiracetam Uses & BenefitsIf you are not familiar with Racetams (Piracetam, Aniracetam, Pramiracetam, Oxiracetam, Coluracetam and others), they are a class of Nootropic drugs that have a 2-pyrrolidone nucleus made up of oxygen, nitrogen and hydrogen but have different properties and indicated effects.

They are known to improve memory, learning capacity, focus, mood, energy levels and positively affect the basic components of brain health.

Phenylpiracetam (N-carbamoylmethyl-4-phenyl-2-pyrrolidone) is a derivative of Piracetam, the first Nootropic ever synthesized with an additional phenyl group attached which acts in improving its bioavailability, ease at crossing the blood-brain barrier and may provide better neuroprotective properties.

In addition to its noted effects on enhancing memory and overall cognition, it is believed to increase the body’s tolerance to stress and cold and offers a stimulant-like effect described by user experience logs as clean enhanced energy and motivation.

This added to the original effects of Piracetam and famously lead to this substance being banned by WADA (World Anti-Doping Agency) for use by professional athletes due to the belief that Phenylpiracetam enhances physical performance.

Phenylpiracetam was originally developed in 1983 and given to Russian cosmonauts to help support mental acuity, alertness and reduce stress when in space for long periods of time.

It is sold in Russia under the brand names Phenotropil and Carphedon, where it is available as both an over the counter drug and prescription medication to help patients in the recovery of strokes, neurological conditions, memory loss, cognitive decline, epilepsy and other conditions.

In addition, this compound is used off-label as a cognitive enhancer to promote focus, reduce brain fog and enhance memory, learning capacity, attention and motivation.

It is also widely available online and growing in popularity due to its touted clean, stimulant-like effects, noted to boost alertness and energy levels without as many side effects when compared to psychoactive drugs like Adderall.

While it is still medically used in Russia and other parts of Eastern Europe, in Western countries it is not used for any medical conditions and is not an approved drug in the U.S by the FDA to prevent or treat any conditions. In the US, Canada, The United Kingdom and Australia, this compound is unregulated and unscheduled which means it is legal to buy, possess and use.

This article will review the reported Nootropic benefits of Phenylpiracetam, some of its reported medical uses, how it works, the potential side effects and dosage guidelines.

Phenylpiracetam Benefits for Cognitive Performance and Mood


As a Nootropic, Phenylpiracetam is used for its many noted benefits on cognition, memory, alertness, mental clarity, focus, concentration and mood in healthy adults. It is commonly touted by users as the strongest and best Racetam to “supercharge your mind’, reduce brain fog, improve cognitive performance, memory and promote higher states of productivity.

Phenylpiracetam is a modified and much more potent version of Piracetam, the first Nootropic ever developed. Researchers suggest that in comparison, it has shown to have greater effects on memory retention, learning capacity and depression.

Additionally, Phenylpiracetam is known for its mild stimulant effects that may help resist mental and physical fatigue which may not only set this Nootropic apart from Piracetam but many others. Anecdotal reports suggest that it works much faster than other Racetams and is thought to have few to no crash effects for most users, even in comparison to caffeine.

Although this compound is touted by many Nootropic users as one of the best Racetams due to its suggested positive effects on both physical and mental performance, there is limited research into its properties and efficacy in healthy adults. Most of the information on the noted powerful effects of Phenylpiracetam come from anecdotal user reviews and experience logs.

User reports describe the experienced effects of Phenylpiracetam as enhancing the ability to process and analyze information with greater ease. The ability to concentrate, learn and retain information is heightened and you experience a more motivated and energetic state making it easier to plug away at mentally demanding tasks with more focus and drive.

In addition, Phenylpiracetam is thought to regulate our response to stress and may reduce both depression and anxiety. In animal studies, Phenylpiracetam has demonstrated to reduce the response to fear when introduced into new environments.

It is also being investigated for its potential mood-enhancing effects and the role it may play in reducing depression. In several studies, Phenylpiracetam has shown to improve depression in patients suffering from some form of cognitive deficits. Many users describe this effect as a powerful boost in mood in conjunction with a very noticeable increase in motivation.

This Nootropic may be a very useful tool for long hours of studying and learning, helping to facilitate enhanced focus, alertness, energy, memory retention and motivation. It may also be useful for business people to help enhance cognition, mental drive, productivity and cope with stressful situations.

Phenylpiracetam

• Enhances Cognitive Performance
• Boosts Attention & Focus
• Promotes Energy & Productivity

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Phenylpiracetam and Athletic Performance


Phenylpiracetam is often used to enhance athletic performance. Bodybuilders, athletes and active people may find this substance to be a great pre-workout tool since it is believed to enhance energy, stamina, endurance and recovery. In addition, it increases the body’s tolerance to stress, including cold, which is an invaluable factor for an athlete.

Many users say that Phenylpiracetam makes them feel energized and promotes feelings of staying power or motivated energy (which is a similar effect to amphetamines) that is clean, focused and without jitters or anxiousness when taken at the appropriate doses.

Professional athletes should note that Phenylpiracetam is a banned substance by WADA (World Anti-Doping Agency) for use in athletic competitions due to the stimulant properties of this drug.

It was reported that in the 2006 Winter Olympic Games, a silver medalist skier was stripped of her medal and banned from the sport for two years by the International Olympic Committee when she tested positive for this substance.

Phenylpiracetam Medical Uses


Phenylpiracetam is sold in Russia under the names Phenotropil and Carphedon. It is primarily prescribed as an anti-asthenic drug or to counteract asthenia which is related to extreme temporary or chronic conditions where the body loses strength, energy and becomes weak, similar to chronic fatigue. In research studies, it has shown to improve problem-solving skills, memory and attention switching in patients with this condition.

In addition, Phenotropil (Phenylpiracetam) is sold as an over the counter drug in Russia and may also be prescribed for use in the treatment of several medical conditions including;

  • Cognitive Impairment
  • Traumatic Brain Injury
  • Alcoholism
  • Obesity
  • Cerebrovascular Disorders
  • Excessive Fatigue
  • Anxiety/Depression/Asthenia after Stroke
  • Neurotic Conditions related to excessive fatigue, memory loss and weakness
  • Epilepsy
  • Prophylaxis For Stress
  • Recovery of Ischemic Strokes

In the United States and in Western countries, it is not used clinically for any medical conditions and is not an approved drug by the FDA to treat or prevent any conditions.

If you are suffering from any of these conditions, it is best to consult with your doctor first to determine whether Phenylpiracetam is appropriate for you and/or if it may interact with any medications you are currently taking.



How Does it Work?


The majority of studies on Phenylpiracetam have only been conducted in Russia and occasionally published in this language. This limits the amount of available information on the mechanisms of actions involved. However, there are some theories on how this compound (Phenotropil) may work but more research is needed to determine any final conclusions.

Research suggests that Phenylpiracetam increases the density of Acetylcholine and NMDA receptors, boosting their effectiveness and increasing the amount of receptors for these neurochemicals to bind to.

These neurotransmitters are thought to be linked to memory formation, attention, reasoning, learning and LTP (long-term potentiation) a process in which long-term memories are stored in the brain.

In addition, it is speculated that this compound may increase extracellular dopamine and norepinephrine levels, blocking their re-uptake and inhibiting the action of transporters.

The stimulatory effects of Phenylpiracetam may be attributed to the increase of dopamine and norepinephrine levels, an action that acts similarly to CNS (central nervous system) stimulants and is thought to be involved in enhanced cognition, alertness, motor control, attention, vigilance and decision-making abilities.

Additionally, it is thought to increase GABA-A receptor density. GABA is a calming neurotransmitter thought to be involved in the balancing of glutamate levels which may help to relax us. This may explain why the promoted energy effects of Phenylpiracetam appears to not cause over-excitation, jitteriness or restlessness.

Finally, being a derivative of Piracetam, it is hypothesized that this compound may increase cerebral circulation, increasing blood flow to the brain and encouraging increased oxygen and nutrient uptake into the brain cells. This may have positive effects on alertness, clarity, focus and mood.

Phenylpiracetam Potential Side Effects


Phenylpiracetam is considered well-tolerated and non-toxic when taken within the appropriate dosages. At this time, there are no known long-term side effects associated with this smart drug and more research is needed to evaluate its safety.

Not everyone responds to Nootropics the same way and you may or may not experience side effects. Some mild adverse side effects may occur and have been reported including headaches, anxiety, nausea, increased perspiration, stomach upset, loss of appetite, brain fog and irritability which may be remedied by taking smaller dosages or cycling this Nootropic agent.

Like all other Racetams, stacking Phenylpiracetam with high-quality choline supplements such as Alpha GPC or Citicoline is highly recommended. This may help to alleviate the potential risk of one of the most common side effects of these types of Nootropics which are headaches. Research also supports that stacking this Nootropic with a choline source may enhance the positive effects on memory and cognition.

Due to the stimulating effect of Phenylpiracetam, high doses are not recommended since this may suggest that it can potentially lead to serious side effects related to toxicity.

Additionally, some users have reported experiencing insomnia and low sleep quality when taking this Nootropic. It is recommended to not take Phenylpiracetam too late in the day to minimize this possibility.

Phenylpiracetam can increase the effects of alcohol when taken in combination. It is highly recommended to not combine these two.

Phenylpiracetam is not recommended for pregnant or nursing women, children or people that are diagnosed with a medical condition due to lack of research on this compound. It is best to speak with your doctor first before using it.

Phenylpiracetam Dosage Guidelines


Phenylpiracetam has a typical recommended total daily dosage range of between 200 mg-300 mg, suggested to be taken in 100 mg doses once in the morning and once in the early afternoon. It is always recommended to start at lower dosage range when first starting a new Nootropic before raising the dosage to first determine how it affects you.

This Nootropic is slightly fat-soluble, as opposed to Piracetam which is water-soluble. This means, that if you are using this compound in powder form, you may want to mix into beverages that contain lipids (fats) such as milk. If you are taking Phenylpiracetam in tablet or capsule form, it is recommended to take it with a meal or a fat source such as olive oil or fish oil.

Tolerance to the effects of Phenylpiracetam are thought to build-up quickly and this Nootropic is recommended to be cycled, one week on and one week off or taken once in a while as needed. In addition, as a precaution, it is not recommended to take this Nootropic every day or on a long-term basis due to a lack of available research at this time.

It is recommended to consult with your doctor or medical professional first before taking this compound to ensure that it is right for you.

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