Pramiracetam Nootropic Review of Effects on Memory, Focus and Clarity

Pramiracetam is a unique member of the Racetam family and one of the strongest Nootropic agents available. It is most commonly used to promote enhanced memory, concentration, mental acuity and especially focus, making it very popular for goal orientated tasks.

Type: Racetam Nootropic
Used For: Memory Enhancement, Focused Productivity, Studying, Mental Alertness, Clarity, ADHD/ADD, Cognitive Performance, Mood
Half-Life: 5hrs-6hrs
Typical Dosage: 300 mg-1,200 mg per day
Some Possible Drug Interactions: Scopalamine
Supplement Interactions: No Known Interactions

What is Pramiracetam?

Pramiracetam is a Nootropic drug belonging to the Racetam class of supplements and one of the strongest. It has grown a reputation as an effective “smart drug” for its recognized benefits on enhancing memory, mental performance, clarity and boosting focused productivity.

What is Pramiracetam?It is one of the highest rated Nootropics and continues to rapidly increase in popularity.

This may be especially due to one of its noted “tunnel-vision effects” described by many users as a noticeable ability to focus on a task while blunting emotional responses, which is an effect that has often been compared by users to Ritalin.

Pramiracetam is a fat-soluble derivative of Piracetam, the first Nootropic ever developed but its amide molecule is substituted with a dipropan-2-ylaminoethyl group, a chemical structure that results in a much higher potency.

If you are not familiar with Racetams, they are a class of Nootropic cognitive enhancing drugs that share a similar chemical structure but have different properties and unique indicated effects. They are known to enhance memory, learning capacity, concentration, focus, mood, energy levels and offer positive effects on the basic elements of brain health.

Pramiracetam (Diisoprop-yl-(2-oxopyrrolidin-1-yl) acetamide, CI879) was developed in the late 1970s by scientists at Parke-Davis & Co. and has continued to be a subject of ongoing research. This was once the largest pharmaceutical company in America and is now a subsidiary of Pfizer.

It is available in parts of Europe as Pramistar, Neupramir, and Remen as Nootropic remedies and prescribed in the treatment of ADHD, dementia, dyslexia and for symptoms of memory disorders and attention deficits in the elderly.

Pramiracetam has been patented in the United States since 1979 but is not approved by the FDA to be used for anything in particular. It is popularly used off-label to promote cognitive enhancement and does not require a prescription to purchase in the U.S., Canada or Australia.

There is little information regarding the legal status of Pramiracetam in the United Kingdom and other parts of Europe, however, thus far it is not a regulated drug in the UK which means it does not fall under the prescription requirements.

Pramiracetam is a favorite among the Racetam class of Nootropics since it has a higher potency than any other Racetam with effects that may optimize brain performance and last all day (for most people) with one dose.

Before trying Pramiracetam, you may want to have a better understanding of how it may enhance mental performance, the additional benefits associated with this Nootropic, the safety and potential side effects and dosage guidelines.

Pramiracetam Benefits for Focus and Memory

The main benefits of Pramiracetam are associated with enhancing memory, learning capacity, focus, clarity, mental alertness and attention span.

This Nootropic has been highly touted as helping users increase their willingness to be productive, enhance mental performance, memory and mental energy levels needed to complete tasks, especially when they require sustained focus and concentration.

One area where Pramiracetam is purported to excel is in its ability to improve memory. It has been observed to boost high-affinity choline uptake (HACU) in the hippocampus.

This is the area of the brain that is thought to be responsible for memory consolidation, which is the process of strengthening, modifying and encoding memories and for spatial memory, the recorded spatial and environment information.

Choline is a precursor to Acetylcholine, a powerful neurotransmitter thought to be highly involved in many cognitive processes including memory formation, the speed at which we learn and process information, the capacity to focus and the ability to concentrate.

This action may positively encourage choline transport and boost Acetylcholine (ACh) synthesis and its circulation within the brain which may result in enhancing all these cognitive processes.

In regards to memory, users online often say that Pramiracetam is one of the best memory enhancers and suggests improvement in frustrating forgetfulness and speeding up the ability to recall memories with much more ease.

Higher levels of available Acetylcholine can also lead to easier and faster flows of knowledge, boost the ability to focus, encourage logical thinking and enhance memory recall without mental strain.

Like most Nootropics, the exact mechanisms of action is still not fully understood and Pramiracetam is still being investigated for its potential effective uses. However, the modulation of ACh currently allows us to have a better understanding of how this Nootropic may work and the reason why it is important, in many cases, to stack it with Choline

Acetylcholine is synthesized from the available Choline in the brain. If there’s a lack of this micronutrient, this Nootropic can cause headaches and mental fatigue. It is suggested to use this Nootropic with a choline source such as Alpha GPC or Citicoline, two high-quality choline sources that may alleviate this risk

Pramiracetam may have a build-up effect. Some people experience the effects right away while others may notice subtle changes with use over time.

Finally, this Racetam has not shown to have additional effects on mood. This Nootropic is more geared towards promoting higher fluid intelligence and mental processing. For mood effects, you may want to consider Aniracetam, another member of the Racetam class of Nootropics.

Pramiracetam Effects on Clarity and Alertness

A major benefit of Pramiracetam is related to increased blood flow to the brain. Proper cerebral circulation increases oxygen uptake which delivers nutrients to the brain promoting alertness, mental clarity and improving the ease of many cognitive processes.

This unique effect is where Pramiracetam was believed to excel above other Racetams. This smart drug has been observed in studies involving rats to increase nitric oxide (NO) in the brain. These are enzymes that relax the blood vessels walls which cause them to open wider.

This results in the increase of blood flow to the cortex, leading to more oxygen and possibly supplying neurons with more glucose, the brains main energy source.

These actions may be responsible for users reporting more alertness, clearer thoughts and enhanced mental energy when using Pramiracetam.

In addition, this can lead to a longer attention span, enhanced concentration and overall faster mental processing and thinking capacities, helping you be more productive and taking on tasks with more flow and ease.

Pramiracetam Side Effects

Pramiracetam is typically well-tolerated by healthy individuals, even at high dosages. It is considered safe, non-addictive and non-toxic with no reports of serious side effects associated with this Nootropic or adverse effects with long-term use.

Like all supplements, it is always recommended to first consult with your doctor or healthcare provider before using or adding a new supplement to your regimen.

The most common side effect of Pramiracetam, which also applies to all Racetams, are headaches. This may be due to their effects on Acetylcholine. It is best to stack this Nootropic with a choline source such as Alpha GPC or Citicoline which may help to eliminate that possibility and may even boost the effects of Pramiracetam.

At higher dosages, you may experience nervousness, agitation or abdominal discomfort which may be avoided by lowering the dosage.

There isn’t enough research to make a conclusion on the safety of this drug if you are pregnant, nursing or planning for pregnancy, as a precaution, this supplement should be avoided.

Pramiracetam Dosage

Pramiracetam has a half-life of approximately 5 hours. The average typical dosage range is between 300 mg-1,200 mg daily, in total. This can be administered in two doses of 300 mg once in the morning and once in the afternoon if you are looking for continued effects throughout the day.

This Nootropic is very potent and large doses aren’t needed. Some people may find lower dosages more effective and it’s a question of finding what works best for you while always staying within the daily suggested dosage range. If you are new to this Nootropic supplement, it is always recommended to start at the lowest effective dose 300 mg once per day before raising the dosage to help you first determine your body’s effect.

Pramiracetam is fat-soluble, so its a good idea to take it with a meal, this also means when taken in powder form it will float to the top of the glass. It is known to have an awful taste so it may be best to take it in capsule or tablet form with some form of healthy fat such as coconut oil, olive oil or fish oil which may additionally enhance absorption or simply with a meal.

It is not recommended to dissolve Pramiracetam powder under your tongue (sublingual) since it has been reported to burn the lining of your mouth.

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