Sulbutiamine Review for Mental Energy, Cognition and Improved Mood

Sulbutiamine

• Promotes Wakefulness, Energy & Focus
• Supports Memory & Mental Performance
• May Improve Mood and Reduce Fatigue

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Sulbutiamine is a synthetic derivative of Vitamin B1 that is capable of crossing the blood-brain barrier easily. As a Nootropic, it is used to promote enhanced concentration, memory, cognition and reported to have powerful positive effects on mood and motivation.

Type: Nootropic Supplement/Vitamin B Derivative
Used For: Energy, Mood Enhancement, Memory, Cognitive Function, Mental Stamina, Focus, Alertness, Anxiety, Motivation, Asthenia, Depression, Libido, Erectile Function
Half-Life: 4hrs-6hrs
Typical Dosage: 200 mg-600 mg per day
Drug Interactions: No Information available
Supplement Interactions: No Information available

What is Sulbutiamine?


Sulbutiamine (brand name Arcalion) is a fat-soluble dietary supplement that is a synthetic, more concentrated version of Thiamine, which is otherwise known as Vitamin B1.

Sulbutiamine Supplement Uses & BenefitsIt is made from bonding two vitamin B1 molecules together which facilitates an easier ability to cross the blood-brain barrier (reach the brain) and increase levels of thiamine and thiamine phosphate esters within the brain at a higher rate of transport.

Sulbutiamine is a type of Nootropic, which is a class of supplements that have shown to help improve several cognitive functions such as memory, focus, learning capacity, decision making and much more.

It was developed in Japan in the early 1970’s, where they were looking for a more effective and bio-available version of standard Thiamine to reverse a widespread medical condition called Beriberi disease (chronic thiamine deficiency). This was due to the high dependency on processed white rice as a source of food after the Second World War, which lacked thiamine and other nutrients.

Thiamine is a coenzyme that plays an important role in metabolizing food to produce energy and especially important for the brain and nervous system. Deficiencies of vitamin B1 (Thiamine) in your diet can lead to acute issues including poor short-term memory, irritability, muscle weakness, lack of thought clarity, short attention span, chronic fatigue, apathy and depression.

With the enhancing effects that Sulbutiamine may have on increasing the energy supply in your brain for better response and efficiency and the purported effects on several important neurochemicals that may help enhance cognitive functions, it is a popularly used as a Nootropic to increase mental energy, enhance focus and working memory.

In addition, it has also been reported to be one of the best supplements for people looking to boost motivation and mood. It seems to defend against fatigue, symptoms of depression, anxiety and chronic stress. The benefits of this supplement also appears to help individuals without deficiencies.

What are the benefits associated with Sulbutiamine? In this article, we will examine the effects of Sulbutiamine on energy, mood and cognition, how it works, potential side effects and dosage guidelines to help you decide whether this Nootropic may work for you.

Sulbutiamine Benefits for Energy and Cognition


Sulbutiamine is considered a top choice supplement if you are looking to boost energy levels, brain power, memory, motivation and cognition.

In user reviews online, the benefits of this Nootropic are often described as similar but cleaner caffeine effects, without leading to jitters or energy crashes which we recognize as feeling more energetic, alert, awake, focused and in a better mood.

Thiamine, the derivative of Sulbutiamine, is a coenzyme that turns nutrients from food into adenosine triphosphate (ATP). This is a high energy molecule that is used to store, carry and maintain energy within the mitochondria of almost all cells and believed to be the energy currency of life.

In addition, thiamine assembles certain enzymes that are used to convert carbohydrates (food) into glucose, the brains main energy source or what is sometimes referred to as “brain sugar“. This may explain why Sulbutiamine is considered to be one of the most popular energy supplements.

The brain is the most energy demanding organ, taking up half of the total energy supply in the body. While taking standard thiamine, which is water-soluble, can help to improve energy and cognition, its rate of absorption is much lower than Sulbutiamine. Lower levels mean less of it reaches the brain, making it much less powerful even when taking thiamine in high doses.

Brain functions such as thinking skills, working memory and learning rely heavily on glucose and its use. Sulbutiamine is very fast acting and may increase the energy supply to your brain much faster and help all the cognitive processes that are working at the same time to run and respond more efficiently. This may have positive effects related to energy levels, mental alertness, attention span and brain power.

Many Sulbutiamine users report that they generally are more aware and alert of their surroundings and have a better ability to process information. This Nootropic may also facilitate faster memory recall, clearer thinking and improved reasoning skills.

Sulbutiamine is thought to boost transmission and communication of brain neurons and positively affect cholinergic, glutamatergic and dopamine receptor sites which can lead to enhanced memory capacity, a greater ability to concentrate and a boost in motivation and mood.

Many students on Amazon product reviews and other forums have noted that using this supplement increases their mental stamina and makes it easier to learn, helping them to withstand long hours of studying with more efficacy.

Others have reported using Sulbutiamine to promote greater motivationproductive levels of energy and easier mental flow to work and complete tasks.

Sulbutiamine is currently being researched for its potential benefits in the treatment of asthenia and other diseases that involve chronic fatigue. It is also being studied as a potential method to help in the treatment of many forms of cognitive decline including Alzheimer’s disease and forms of schizophrenia.

While the exact effects and actions of Sulbutiamine are not fully understood and the research is limited, it is available at this time as only a dietary supplement in the U.S which is not approved by the FDA to treat or prevent any conditions.

Sulbutiamine

• Promotes Wakefulness, Energy & Focus
• Supports Memory & Mental Performance
• May Improve Mood and Reduce Fatigue

SHOP NOW

Sulbutimiane Effects on Mood and Anxiety


Sulbutiamine has been observed anecdotally to have positive effects on general mood, particularly reviewed by users as ideal for reducing feelings of anxiety and stress. This may due to this supplements ability to stimulate dopamine receptors in the brain in addition to promoting energy.

Dopamine is a chemical in the brain that is thought to be directly related to our mood and how vigorously we will work towards a goal or desire (motivation). It is involved in the sensation of pleasure, feelings of well being, movement, memory and the ability to focus and pay attention.

Sulbutiamine is thought to stimulate dopamine receptor sites. This may be a contributing factor to why many user reports suggest that taking this supplement results in huge boosts of motivation, a happier state of mind and a better ability to focus and concentrate on tasks.

Although Sulbutiamine is not categorized as an anxiolytic (used to reduce anxiety), by increasing dopamine receptor site activity, it may encourage more positive moods and that may help you to respond better to stressful situations.

Sulbutiamine seems to be used anecdotally to counteract depression, social phobias, shyness and social anxiety. Many people have found it to be effective for them at reducing anxious thoughts and helping them relax which may encourage more confidence.

Particularly, if you are considered using Sulbutiamine for social anxiety relief, the results may be more effective when taken in combination (stacks) with other compounds such as Aniracetam and a choline supplement such as Alpha GPC or Citicoline.

Finally, there are some recent studies on the effects of Sulbutiamine indicating that it may help in treating erectile dysfunction, however, more research is needed to determine its efficacy for this use.

More scientific and medical research is needed to understand the full effects and actions of Sulbutiamine. This compound is not approved by the FDA to treat or prevent any conditions.

How does Sulbutiamine Work?


Sulbutiamine is a lipophilic molecule (dissolves in fats), that has a much higher bioavailability than standard Thiamine, which is water-soluble and flushes out of the body if it is not replaced.

Although there is limited research on all the effects of Sulbutiamine and the mechanisms of action are not fully understood, scientists have come up with a working thesis as to how this Nootropic may work.

When using Sulbutiamine, more thiamine intake is absorbed into the blood and the efficiency of transport from the bloodstream to the brain is increased, perpetrating stronger results.

This allows Sulbutiamine to easily cross the blood-brain barrier, which is an imperative factor to attain any cognitive effects. It is then broken down into Vitamin B1 and other related esters, increasing thiamine and thiamine phosphate levels within the brain to a much higher extent than an equal dose of standard thiamine.

This mimics the effects of thiamine, on a much more concentrated level, which can lead to stronger benefits on energy levels and mood. In addition, Thiamine intake has been linked to improvements in anxiety levels, helping your body withstand stress.

Sulbutiamine is thought to interact with several receptor sites and improve neurological transmission of DopamineGlutamate and the production of Acetylcholine. These are brain chemical messengers that are thought to influence vital cognitive functions and processes such as concentration, attention, memory formation and retrieval, learning, mood and executive functions.

This thiamine derivative is thought to help improve many cognitive processes including problem-solving, decision making, planning skills, learning capacity and boosting memory. This may be a result of the potential modulation of Glutamate which may contribute to the Nootropic effects of Sulbutiamine.

Dopamine, in particular, is a neurotransmitter involved in both mood and aspects of cognition. It promotes feelings of happiness, a positive state of mind and counteracts symptoms of depression and anxiety.

Sulbutiamine is thought to reduce the natural release of dopamine in the prefrontal cortex which in turn, may increase dopamine receptor density. An increase in the number of dopamine receptors in the brain may not only lead to enhanced mood but also promotes improvements in your ability to focus and may boost your level of motivation.

Finally, thiamine produces Acetylcholine (ACh). This is a neurotransmitter that sends signals across the synapses to other neurons and is linked to concentrationmemory and learning capacity.

Sulbutiamine is currently available in the United States as a health supplement only. Research and studies on Sulbutiamine are still limited. It is not approved by the FDA to treat or prevent any conditions.

The suggested typical dosage range is between 200 mg and a maximum of 800 mg daily as needed, not to be exceeded within a 24 hour period. Most users report taking 200 mg once or twice daily. Sulbutiamine is fat soluble,  so it is recommended to take it with milk, a fat source such as olive oil or with a meal.

It is important to note that you can build up a tolerance to Sulbutiamine. The positive effects can wear off quickly with consistent use. The best way to avoid this is to cycle this supplement (take breaks) and use it only when needed.

In addition, some users have reported experiencing low energy levels and/or feelings of sadness as the effects wear off. Sulbutiamine has a half-life of approximately 4-6 hours. You may want to consider taking other mood enhancing Nootropics such as Mucuna Pruriens or L-Tyrosine 3-4 hours after taking Sulbutiamine to prevent a decline in mood



Sulbutiamine Side Effects


Sulbutiamine is considered to be very well tolerated and carries a low risk of potential, harmful side effects when used appropriately and in moderation for a short period of time.

Mild side effects may occur in some people including skin irritation or eczema-like skin reactions. These occurrences have been reported to be short-lived and moderate but can potentially pose the risk of being more serious. It is always best to speak with your doctor first about other risk factors and dosage recommendations before trying a new supplement.

Prolonged use of Sulbutiamine may result in adverse side effects such as mood swings and malaise. The dosage or frequency of use may be too high or for some, the receptors in the brain can be overly sensitive to the effects of Sulbutiamine. To avoid this, it is recommended to only take this supplement on an occasional basis and the appropriate recommended dosage. If it continues, discontinue use entirely.

Sulbutiamine may have mild stimulating effects for some people which may depend on personal brain chemistry. This may interfere with the ability to fall asleep, especially if taken too late in the day.

This supplement is known to suppress your appetite. If you have a history of eating disorders or you are currently underweight you may want to avoid it.

Sulbutiamine may interact negatively with other medications. It is especially NOT recommended for people who are currently taking medication for bipolar disorder or for those who are taking anti-depressants or stimulants. It is best to speak with your doctor first about the risks of side effects based on your medical history before using this supplement.

This supplement is known to affect dopamine levels in the brain. There have been reports that Sulbutiamine may be addictive for some people but there is no conclusive research that this supplement is habit-forming.

In general, it is recommended to use Sulbutiamine on an occasional basis as needed and avoid long-term useto prevent potential side effects or tolerance.

Sulbutiamine Dosage & Tolerance


The proper dosage of Sulbutiamine is difficult to determine since it is based on many factors such as weight, age, personal natural metabolism and your general health and tolerance.

Dosage recommendations listed here should be used as a general guideline only. Before determining if any supplement is right for you, it is recommended to consult with your doctor first.

Sulbutiamine is available in capsules, tablets and powders. The average recommended dosage can vary from person to person, meaning how much or how little will work for you (or not at all).

You may want to experiment but it is always recommended to stay within the lowest dose available when starting on any new supplement. This helps you gauge your body’s effect and response to find what works best for you before raising the dose.

The suggested typical dosage range is between 200 mg and 600 mg daily as needed. Most users report taking 200 mg once or twice daily. Sulbutiamine is fat soluble, so it is recommended to take it with milk, a fat source such as olive oil or with a meal.

It is important to note that you can build up a tolerance to Sulbutiamine. The positive effects can wear off quickly with consistent use. The best way to avoid this is to cycle this supplement (take breaks) and use it only when needed.

In addition, some users have reported experiencing low energy levels and/or feelings of sadness as the effects wear off. Sulbutiamine has a half-life of approximately 4-6 hours. You may want to consider taking other mood enhancing Nootropics such as Mucuna Pruriens or L-Tyrosine 3-4 hours after taking Sulbutiamine to prevent a decline in mood.

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